A complete enteric-protected nattokinase formula stacked with K2 and CoQ10. Dissolves fibrin buildup, redirects calcium out of arteries, and powers the heart at the mitochondrial level.
Nattokinase NSK-SD® 2,000 FU
Dissolves fibrin, restores smooth blood flow
K2 MK-7 (MenaQ7®) 180mcg
Directs calcium out of arteries, into bones
CoQ10 Ubiquinol 100mg
Mitochondrial energy for the heart muscle
NIKAI™ Dual-Layer Delivery Enteric protection
Enzyme stays active
No Magnesium Stearate
Clean formulation, full bioavailability
Third-party tested & certified
cGMPcertified
NONGMO
3rd partyLabtested
MadeinUSA
60
60-Day Money Back Guarantee
Tested by Light Labs inFEB 2026
3 substances tested for quality
"This is the cardiovascular formula I recommend to patients focused on healthy aging. Most nattokinase supplements are destroyed by stomach acid before they reach circulation — NIKAI™ enteric delivery solves the one problem that defines whether the enzyme actually works."
Cardiovascular Longevity & Metabolic Health
Dr. Michael Chen, MD
"The combination matters. Nattokinase clears fibrin. K2 directs calcium out of the arteries where it doesn't belong. CoQ10 powers the heart at the mitochondrial level. Three mechanisms, one capsule, working on three different layers of vascular aging."
Cellular Biology & NAD+ Metabolism
Dr. Yuki Tanaka, PhD
Unlike most brands, we validate every ingredient and prove its purity with independent third-party testing.
Tap below to view our lab results.
Unlike most brands, we validate every ingredient and prove its purity with independent third-party testing.
Tap below to view our lab results.
Creatine supports your body's primary energy system — the phosphocreatine pathway — which fuels strength, focus, and recovery. As we age, creatine synthesis declines by up to 1–2% per year, quietly accelerating muscle loss, cognitive slowdown, and reduced resilience.
When taken daily, it helps:
• Preserve lean muscle mass and prevent age-related loss
• Support cognitive performance & stress resilience
• Fuel sustained energy throughout the day
• Speed up recovery from training or physical strain
• Protect long-term healthspan at the cellular level
Creatine works best when used consistently.
Yes — that's exactly what NIKAI™ solves. Standard capsules let stomach acid destroy as much as 80% of the active dose. NIKAI™ dual-layer enteric coating holds the capsule intact through the stomach and releases it in the small intestine, where bioavailability reaches up to 99%.
After 40, your cardiovascular system slows down on three fronts. Fibrin builds up faster than your body clears it, narrowing blood flow. Calcium drifts from bones into arterial walls, stiffening vessels. CoQ10 levels drop 50%, leaving the heart muscle running on less fuel. This formula reactivates all three — in one capsule.
Anyone over 40 noticing slower circulation, rising blood pressure, or family history of heart disease. Especially relevant for post-menopausal women, professionals with high-stress lifestyles, biohackers tracking vascular age markers, and anyone on statins — which deplete the body's natural CoQ10 levels.
Most users notice steadier energy and lighter circulation within the first 2 weeks. Deeper changes — blood pressure stabilization, vascular elasticity, vascular age markers — compound between weeks 4 and 12. Minimum protocol: 60 days.
60-day money-back guarantee. Full refund. No forms. No questions asked.
1 in 3 adults dies from cardiovascular disease— the world's #1 killer.Blood thickens. Arteries harden. Heart fuel runs out.*
Vascular age can outpace your passport by 15 years. Cardiovascular decline is silent – what you feel is the damage it's already done. This formula was built to reverse it.
*Based on World Health Organization reports, 2023
Fibrin is supposed to clot wounds, then clear away. After 40, fibrin clearance slows by up to 60%. Excess fibrin thickens blood, narrows flow, and forces the heart to work harder for the same delivery.
Without K2, calcium drifts from bones into arterial walls — exactly where it doesn't belong. By 60, arterial stiffness has risen ~30%. Stiff arteries raise blood pressure and cardiovascular risk.
The heart muscle produces 6,000 ATP molecules per second to keep beating. CoQ10 fuels that production — and your levels drop ~50% by age 40. The most metabolically demanding organ runs on less fuel.
Sluggish circulation means muscles, brain and tissues receive less oxygen and fewer nutrients per beat. Recovery slows. Cognitive clarity dulls. Energy flatlines by mid-afternoon.
Vascular age can outpace passport age by 10–15 years. Faster vascular aging predicts mortality more accurately than chronological age. The arteries are where the body ages first.
3 Cardiovascular Ingredients. One Capsule Against Vascular Aging.
The first oral nattokinase formula stacked with K2 and CoQ10 – and protected by enteric delivery so the enzyme actually reaches your bloodstream.
The fibrinolytic enzyme isolated from natto – Japan's centuries-old longevity food. Dissolves excess fibrin in the bloodstream, restoring smooth circulation and oxygen delivery to every cell.
NSK-SD® · the only nattokinase form with full clinical research backing
The calcium traffic controller. Activates matrix Gla-protein – directing calcium out of arterial walls and into bones, where it belongs. Without K2, calcium drifts to exactly the wrong places.
MenaQ7® · the most bioavailable K2 form, validated in 20+ clinical trials
The active form of CoQ10 – already converted, ready for use. Powers ATP production in the heart muscle's mitochondria. Levels drop ~50% by age 40; this is what brings them back.
Ubiquinol · 8× more bioavailable than standard CoQ10
Nattokinase NSK-SD® 2,000 FU
The fibrinolytic enzyme isolated from natto – Japan's centuries-old longevity food. Dissolves excess fibrin in the bloodstream, restoring smooth circulation and oxygen delivery to every cell.
NSK-SD® · the only nattokinase form with full clinical research backing
3rd party lab tested
800+ clinical studies
Cruelty-free
99.9% purity standard
cGMP certified facility
Made in USA
Research grade ingredients
No gluten
No dairy
No artificial colors & flavors
No sugar & sweeteners
Vegan
Watch NIKAI™ Cardiovascular Stack Transform Your Biology
Nattokinase works best when used consistently. The longer you take it, the cleaner your circulation runs.
Week 1–2
FIBRIN CLEARANCE BEGINS
Nattokinase dissolves excess fibrin within hours. CoQ10 saturates cardiac mitochondria. Energy stabilizes – afternoon crashes fade. Hands and feet feel warmer.
Week 2+
CIRCULATION OPENS UP
Blood flows more efficiently through narrowed vessels. Oxygen delivery rises. Recovery between workouts shortens. Mental clarity sharpens – your brain runs on better fuel.
Week 4+
VASCULAR REPAIR
K2 redirects calcium out of arterial walls. Vessel elasticity improves. Blood pressure stabilizes within healthy range. Heart works less for the same output.
Week 6+
DEEP CARDIOVASCULAR RESET
Your blood clears clots faster than it has in years. Heart cells run on full energy again. ATP production reaches peak efficiency – energy rises from within.
Week 8+
WHERE CARDIO SHIFTS LOCK IN
Cardiovascular markers – fibrinogen levels, vascular stiffness, resting heart rate – stabilize at an improved baseline.
Month 3+
VASCULAR AGE REVERSES
Arterial elasticity keeps improving. Blood pressure, lipid profile, and inflammatory markers improve. Your vascular age moves back toward – and below – your passport age.
Why NIKAI™Cardiovascular StackIs Not Like Other Nattokinase
Most nattokinase is built to support circulation. NIKAI™ is built for cardiovascular longevity over the next 40 years.
Feature
TUDO NIKAI™
Other Brands
Nattokinase to dissolve fibrin
K2 MK-7 to clear arterial calcium
CoQ10 Ubiquinol for heart energy
Stomach acid-resistant capsule
99.9% purity
Third-party tested
Zero artificial fillers
What Happens When You Take NIKAI™ Cardiovascular Stack Daily
600+ clinical studies back this formula. Our customers confirm it every day.
Felt lighter with reduced tension and smoother daily energy within 30 days
87%
Reported improved circulation and reduced heaviness in legs and feet
81%
Noticed steadier heart rhythm and less tension during exercise
76%
Measured improvement in vascular age markers after 3 months
Your 10-Second Daily Cardiovascular Ritual
Two capsules. Once a day. Take back the 15 years your vascular age has gained.
01
02
03
TWO CAPSULES. WATER. DONE.
Take 2 capsules with a full glass of water. Ten seconds, every day.
TAKE THEM ON AN EMPTY STOMACH.
Best in the morning before breakfast, or in the evening 2 hours after your last meal.
MAKE IT AUTOMATIC.
Daily consistency is what shifts your vascular age back the 15 years it gained.
Engineered in Japan —
Where Longevity Is an Industrial Standard.
Japan has more centenarians per capita than any nation on Earth. It's also the country with the strictest supplement manufacturing standards in the world — and that's not a coincidence. A nation that takes longevity seriously doesn't separate "supplement-grade" from "pharma-grade." To them, it's one discipline: the same GMP, the same documentation on every gram, the same precision used to manufacture prescription drugs.
We call this discipline the NIKAI PRECISION CODE™ — and it's the foundation of every Tudo formula. In NIKAI™ Nattokinase + K2 + CoQ10, where the active enzyme has Japanese roots going back centuries, it shows up as:
NIKAI™ 二階 Dual-Layer Delivery — capsule-in-capsule engineering. Outer enteric shell protects nattokinase from stomach acid. Inner capsule releases in the small intestine, where the enzyme reaches circulation intact.
WAKŌ™ 和光 99.9%+ Purity — multi-stage recrystallization to Japanese research-grade standards. Not supplement grade. Not pharmaceutical grade. Research grade.
Japanese-rooted formulation — nattokinase isolated from natto, a traditional fermented food behind Japan's cardiovascular longevity
Athletes, Biohackers, Age Optimizers, Professionals
— 22,000+ Verified Buyers
Robert M., 56
Retired Surgeon
"I know what nattokinase does and how rare proper enteric delivery is in this category. The math made me try it. The results made me stay: blood pressure is steadier, energy is higher, and I'm sleeping deeper than I have in five years."
"Spent the last decade slowly losing endurance – stairs, walks, anything sustained. Six weeks on this and I climbed three flights without thinking about it. Forgot what that felt like."
"Sit 11 hours a day, fly twice a month. Used to feel my heart pound when I stood up after a long flight. That sensation is gone. Energy through afternoon meetings is also noticeably steadier."
"Stress made my heart feel like it was racing for hours after intense days. Six weeks on this and that's calmed down significantly. Focus is sharper, recovery is faster."
"After menopause my BP started creeping up and weekend hikes wore me out fast. Two months in – readings back to normal, and I'm finishing the same trails without stopping."
"I'd written off the heaviness in my legs as just getting older. Three weeks in, that feeling I assumed was permanent – gone. Wearing fitted jeans without thinking about it again."
"Tracking everything. HRV up, resting heart rate down, vascular age trending 4 years younger after 90 days. Most nattokinase products give you one ingredient – this one gives you three working together."
"Run all the longevity tests. After 4 months on this, my arterial scan showed measurable improvement. Not many supplements where I can point to a number and say it's actually working."
"Family history of heart disease runs deep on both sides – dad had a heart attack at 58. This is the first thing I've taken where my next physical actually showed numbers moving in the right direction. My cardiologist asked what I was doing differently."
"Grandfather, father, uncle – all gone before 65. I started this at 38 because I want to be there for my kids. Three months in, my numbers are better than they've been since I started tracking them at 30."
Backed by leading longevity scientists and physicians
Tudo formulas are developed, reviewed, and endorsed by independent experts in longevity medicine, neuroscience, and muscle physiology.
"
Most nattokinase fails at the same point – stomach acid destroys the enzyme before it reaches circulation. NIKAI™ enteric delivery is the first oral formula where the active dose actually arrives intact.
"
Dr. Michael Chen, MDCardiovascular Longevity & Metabolic Health Mayo Clinic
"
"Three layers of vascular aging in one capsule. Nattokinase clears fibrin, K2 redirects calcium, CoQ10 restores cardiac mitochondrial energy. I haven't seen this combination delivered orally before."
"
Dr. Yuki Tanaka, PhDCellular Biology & Mitochondrial Research Osaka University
"
Nattokinase is an enzyme – bioavailability isn't a nice-to-have, it's the entire game. Standard capsules deliver as little as 20%. NIKAI™ brings it closer to 99%.
"
Dr. Jonathan Park PhDPharmaceutical Sciences & Nutrient BioavailabilityJohns Hopkins University
"I'm 58. My blood pressure was creeping up the last few years. Three months on this and the readings dropped back into normal range. My doctor noticed."
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Diana K.
Verified Buyer
I recommend this product
Wellness concern:Menopause, Heart, Hiking
Age Range:45-54
Gender:Female
Usage:1-3 month
NIKAI Nattokinase + K2 + CoQ10
"After menopause my BP started creeping up and weekend hikes wore me out fast. Two months in — readings back to normal, finishing the same trails without stopping."
Was this reviews helpful?
Steven W.
Verified Buyer
I recommend this product
Wellness concern:Travel, Energy, Heart rhythm
Age Range:45-54
Gender:Male
Usage:1-3 month
NIKAI Nattokinase + K2 + CoQ10
"I sit 11 hours a day and fly twice a month. My heart used to pound when I stood up after long flights. That's gone now."
"Heart disease runs deep on both sides of my family. My dad had a heart attack at 58. This is the first thing where my labs actually moved in the right direction. My cardiologist asked what I was doing differently."
"Grandfather, father, uncle — all gone before 65. Started this at 38 because I want to be there for my kids. Three months in and my numbers are the best they've been since I started tracking."
Was this reviews helpful?
Marco B.
Verified Buyer
I recommend this product
Wellness concern:Vascular age, HRV, Longevity
Age Range:35-44
Gender:Male
Usage:6+ month
NIKAI Nattokinase + K2 + CoQ10
"My Whoop shows resting heart rate down 4 points and HRV up since I started. Six months in. Sticking with it."
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Frank D.
Verified Buyer
I recommend this product
Wellness concern:Endurance, Stairs, Healthy aging
Age Range:55-64
Gender:Male
Usage:3-6 month
NIKAI Nattokinase + K2 + CoQ10
"Spent the last decade slowly losing endurance. Six weeks in and walks feel easier. Forgot what that felt like."
Was this reviews helpful?
Emily T.
Verified Buyer
I recommend this product
Wellness concern:Stress, Heart rate, Focus
Age Range:35-44
Gender:Female
Usage:1-3 month
NIKAI Nattokinase + K2 + CoQ10
"Stress made my heart feel like it was racing for hours after intense days. Six weeks on this and that's calmed down a lot. Recovery after long days feels faster too."
Was this reviews helpful?
Tom J.
Verified Buyer
I recommend this product
Wellness concern:Cardio, Endurance, Cycling
Age Range:35-44
Gender:Male
Usage:1-3 month
NIKAI Nattokinase + K2 + CoQ10
"Started for endurance on long climbs. The tight chest feeling at altitude — that's not happening anymore."
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Carol W.
Verified Buyer
I recommend this product
Wellness concern:Statins, CoQ10, Energy
Age Range:55-64
Gender:Female
Usage:3-6 month
NIKAI Nattokinase + K2 + CoQ10
"My doctor said statins were depleting my CoQ10 and that's why I felt tired all the time. The CoQ10 in this is the only one that actually made a difference for me."
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Patrick H.
Verified Buyer
I recommend this product
Wellness concern:Convenience, Daily routine
Age Range:45-54
Gender:Male
Usage:1-3 month
NIKAI Nattokinase + K2 + CoQ10
"Easier than taking three separate supplements."
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Linda B.
Verified Buyer
I recommend this product
Wellness concern:Heavy legs, Circulation, Energy
Age Range:45-54
Gender:Female
Usage:1-3 month
NIKAI Nattokinase + K2 + CoQ10
"My legs felt heavy by 3pm every day. After about a month on this they don't anymore. Hands are warmer too."
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Greg O.
Verified Buyer
I recommend this product
Wellness concern:Heart, Blood pressure
Age Range:55-64
Gender:Male
Usage:3-6 month
NIKAI Nattokinase + K2 + CoQ10
"Slowly working. Steady progress is fine by me."
Was this reviews helpful?
Anna F.
Verified Buyer
I recommend this product
Wellness concern:Heart rate, Sleep, Stress
Age Range:35-44
Gender:Female
Usage:1-3 month
NIKAI Nattokinase + K2 + CoQ10
"My resting heart rate dropped 5 beats over the last month. Sleeping deeper too."
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Brian K.
Verified Buyer
I recommend this product
Wellness concern:Heart, Energy, Quality
Age Range:35-44
Gender:Male
Usage:1-3 month
NIKAI Nattokinase + K2 + CoQ10
"Tried two other nattokinase brands before. Didn't really feel anything. This one I noticed within a few weeks."
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Susan M.
Verified Buyer
I recommend this product
Wellness concern:Healthy aging, Energy, Family
Age Range:55-64
Gender:Female
Usage:3-6 month
NIKAI Nattokinase + K2 + CoQ10
"I'm 60. Walking the dog with my husband again — used to send him alone because I'd be tired by the time we got around the block."
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Daniel L.
Verified Buyer
I recommend this product
Wellness concern:Recovery, Endurance, Running
Age Range:35-44
Gender:Male
Usage:1-3 month
NIKAI Nattokinase + K2 + CoQ10
"Resting heart rate dropped 6 bpm. Recovery between long runs is faster. The heaviness in my legs after races is gone."
"Two weeks in. Will check with my doctor at next labs."
Was this reviews helpful?
Christopher S.
Verified Buyer
I recommend this product
Wellness concern:Energy, Heart rate, Stress
Age Range:45-54
Gender:Male
Usage:1-3 month
NIKAI Nattokinase + K2 + CoQ10
"My heart used to feel like it was working hard for no reason during the day. That's calmed down. Energy is steadier through afternoon meetings."
Was this reviews helpful?
Helen R.
Verified Buyer
I recommend this product
Wellness concern:Circulation, Hands, Feet
Age Range:55-64
Gender:Female
Usage:1-3 month
NIKAI Nattokinase + K2 + CoQ10
"My fingers and toes used to be cold all the time, even in summer. Three weeks in and they're warm. Small thing but means a lot."
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Mark T.
Verified Buyer
I recommend this product
Wellness concern:Performance, Workout, Endurance
Age Range:35-44
Gender:Male
Usage:1-3 month
NIKAI Nattokinase + K2 + CoQ10
"Lifting feels different. Like I'm not gassed as quick between sets."
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Risk-Free
Feel it, or get your money back.
All Batches Are 3rd Party Lab Tested
Every batch is independently tested for enzymatic activity, identity, and purity to WAKŌ™ 99.9%+ research-grade standards. We publish results so you can verify exactly what's in every capsule.
60-Day Risk-Free Trial
Cardiovascular renewal works gradually – fibrin clearance, calcium redistribution, and mitochondrial recovery take weeks, not days.
Give your body the minimum protocol: 60 days. If you don't feel a difference, contact us for a full, hassle-free refund.
Simple, Hassle-Free Refunds
We don't believe in forcing belief.
If NIKAI™ Nattokinase + K2 + CoQ10 doesn't meet your expectations, our support team will process your refund quickly. No forms. No questions asked.
Over 22,000 verified buyers. 4.9/5 average rating. We're confident enough to bet on your experience – because 87% of our customers report improved circulation and energy within the first 30 days.
FAQs
The first oral nattokinase formula stacked with K2 and CoQ10 – and protected by NIKAI™ enteric delivery so the enzyme actually reaches your bloodstream. Nattokinase dissolves fibrin and restores smooth circulation. K2 directs calcium out of arterial walls and into bones. CoQ10 powers cardiac mitochondria. Three mechanisms, working on three layers of vascular aging.
Anyone over 40 noticing slower circulation, rising blood pressure, family history of heart disease, or accelerated vascular aging. Especially relevant for post-menopausal women, professionals with high-stress lifestyles, and anyone on statins (which deplete CoQ10).
Yes. Nattokinase is an enzyme, and standard capsules let stomach acid destroy as much as 80% of the active dose. NIKAI™ dual-layer enteric coating holds the capsule intact through the stomach and releases it in the small intestine, where bioavailability reaches up to 99%.
Most brands offer nattokinase alone, in a standard capsule, at generic-grade purity. NIKAI™ stacks it with K2 MK-7 (MenaQ7®) and CoQ10 Ubiquinol and delivers them through dual-layer enteric protection. Nattokinase form is NSK-SD®, the only version with full clinical research backing.
Yes. Within the first 60–90 days, most users see improvements in resting heart rate, blood pressure stability, HRV, and energy levels. Biohackers tracking advanced markers (vascular age, IMT, lipid panels, fibrinogen) often see measurable shifts at the 3–4 month mark.
60-day money-back guarantee. Full refund. No forms. No questions asked. That's also the minimum protocol we recommend – cardiovascular renewal compounds gradually, so we ask for 60 days before judging the result.
Two capsules once a day. Best in the morning before breakfast, or in the evening 2 hours after your last meal. NIKAI™ enteric delivery works best when the stomach is empty.
Most users notice steadier energy and lighter circulation within the first 2 weeks. Deeper changes – blood pressure stabilization, vascular elasticity, vascular age markers – compound between weeks 4 and 12. Minimum protocol: 60 days.
Consult your physician first. Nattokinase has natural fibrinolytic activity, and combining it with prescription blood thinners (warfarin, aspirin, anticoagulants) can amplify their effect. This is the most important conversation to have with your doctor before starting this protocol.
Generally yes – and CoQ10 supplementation is especially relevant for anyone on statins, since these medications deplete the body's natural CoQ10 levels. Many cardiologists actively recommend CoQ10 alongside statin therapy. Always consult your physician before adding any supplement to a prescription regimen.
Yes – designed as part of the full Tudo Longevity Protocol. NIKAI™ Nattokinase + K2 + CoQ10 covers the cardiovascular layer. Pair with MIKRON™ Creatine for muscle and brain, SHINKAI™ NMN for cellular energy, and NIKAI™ BPC-157 + Epithalon for tissue repair.
Yes. Discontinue NIKAI™ Nattokinase + K2 + CoQ10 at least 2 weeks before any planned surgery, dental procedure, or invasive treatment. Nattokinase has natural fibrinolytic activity, and your medical team needs your clotting function at baseline during procedures. Resume after your physician confirms you've fully recovered.
Nattokinase is derived from fermented soybeans (Bacillus subtilis natto fermentation), so trace soy proteins may be present. If you have a severe soy allergy, consult your physician before use. The K2 (MenaQ7®) and CoQ10 Ubiquinol are not soy-derived. Capsules are vegan, plant-based HPMC. No gluten, dairy, or magnesium stearate.
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TUDO NIKAI™
Based on 257 verified reviews
Based on 257 verified reviews
