"NMN is among the most direct interventions we have for NAD+ restoration. What makes this formula exceptional is the addition of Apigenin — blocking CD38 is the missing piece most NAD+ supplements completely ignore."
Epigenetics & Biological Age Research
Dr. Elena Vasquez PhD
"By age 40, NAD+ levels may be less than half of what they were at 20. SHINKAI™ phospholipid delivery changes the bioavailability equation entirely. This is the standard NAD+ supplementation should be held to."
Cellular Biology & NAD+ Metabolism
Dr. Yuki Tanaka PhD
Unlike most brands, we validate every ingredient and prove its purity with independent third-party testing.
Tap below to view our lab results.
Unlike most brands, we validate every ingredient and prove its purity with independent third-party testing.
Tap below to view our lab results.
The world's first triple-action NAD+ formula — 500mg NMN restores NAD+ levels, 100mg Apigenin blocks CD38 (the enzyme that destroys NAD+), and 500mg TMG protects DNA methylation. Delivered via SHINKAI™ phospholipid technology for 3–5x higher bioavailability than standard forms.
Anyone over 30 who wants to maintain cellular energy, protect their brain, slow biological aging, and extend healthspan. Especially effective for professionals under cognitive load, active adults over 40, women navigating hormonal changes, and anyone focused on longevity.
Take 2 capsules every morning on an empty stomach — 30 minutes before breakfast. Consistency matters more than timing. The longer you take it, the deeper the cellular renewal goes.
Week 1–2: more stable energy, less afternoon fatigue. Week 4+: improved sleep quality, sharper mental clarity. Week 6+: cognitive function measurably improves, recovery accelerates. Week 12+: biological age markers begin to shift. Month 6+: sustained NAD+ restoration creates measurable changes in healthspan.
SHINKAI™ is a phospholipid encapsulation technology inspired by deep-sea biology. It wraps NMN molecules in protective lipid layers that survive digestion and deliver active compounds directly into cells — increasing bioavailability 3–5x compared to standard capsules.
Yes — it works synergistically with the full Tudo Protocol. If you take prescription medications, consult your physician before use.
By 40, your NAD+ levelshave dropped by 50%Energy loss. Cognitive decline. Accelerated biological aging.
You feel it every day. And left unaddressed, it quietly shortens both your healthspan and your lifespan. If any of these feel familiar – this formula was built for you.
*Based on peer-reviewed studies, PubMed
Without adequate NAD+, your mitochondria can't produce ATP efficiently. Every cell in your body runs on less fuel than it should.
NAD+ powers brain cell repair and neurotransmitter function. Low levels are directly linked to brain fog, memory loss, and slower thinking.
NAD+ activates sirtuins – the longevity enzymes that regulate cellular repair. Without them, biological age accelerates faster than chronological age.
As NAD+ declines, your body loses its ability to repair daily DNA damage. The errors accumulate – and age you from the inside out.
NAD+ is central to how your body converts food into energy. Low levels mean slower metabolism, more fatigue, and reduced resilience under stress.
4 Longevity Ingredients. Clinical Formula Against Root Causes of Aging.
The world's first triple-action NAD+ formula – NMN, Apigenin, and TMG working in synergy, delivered by SHINKAI™ phospholipid technology.
The most direct NAD+ precursor available. Restores cellular energy production, activates sirtuins – the longevity enzymes – and supports DNA repair capacity.
Clinically validated in 800+ studies
Not an optional booster – a metabolic necessity. NMN consumes methyl groups during conversion. Without TMG, NMN supplementation creates a methylation deficit that accelerates biological aging.
Essential cofactor for NMN
The only natural CD38 inhibitor with sufficient clinical evidence. CD38 is the enzyme that destroys NAD+ faster than your body can replenish it. Apigenin blocks it – protecting every milligram of NMN you take.
The missing piece in standard NAD+ formulas
Patented absorption amplifier. Activates SGLT1 and GLUT4 transporters — ensuring every milligram of this formula reaches your cells.
+67% bioavailability, patented
NMN (Nicotinamide Mononucleotide) 500mg
The most direct NAD+ precursor available. Restores cellular energy production, activates sirtuins – the longevity enzymes – and supports DNA repair capacity.
Clinically validated in 800+ studies
3rd party lab tested
800+ clinical studies
Cruelty-free
99.9% purity standard
cGMP certified facility
Made in USA
Research grade ingredients
No gluten
No dairy
No artificial colors & flavors
No sugar & sweeteners
Vegan
Watch SHINKAI™ NAD+ Transform Your Biology
The longer you take it, the deeper the cellular renewal goes.
Week 1–2
CELLULAR ENERGY BEGINS RESTORING:
NAD+ precursors accumulate in cells. Mitochondrial function improves. More stable energy and less afternoon fatigue within two weeks.
Week 2+
SIRTUIN ACTIVATION:
As NAD+ rises, sirtuin enzymes activate – triggering DNA repair, cellular cleanup, and metabolic regulation. Brain fog lifts. Mental clarity sharpens.
Week 4+
DEEP CELLULAR REPAIR:
Cells repair DNA faster. Inflammation balance reduces. Sleep quality improves as cellular recovery during rest becomes more efficient.
Week 6+
COGNITIVE & METABOLIC ACCELERATION:
Memory and focus sharpen. Metabolic efficiency improves – energy conversion from food becomes more effective. Cellular performance shifts to a younger biological state.
Week 12+
BIOLOGICAL AGE MARKERS SHIFT:
NAD+ levels reach optimal range. Epigenetic aging markers reverse. Endurance, cognitive output, and recovery reach a new baseline.
Noticed sharper focus and improved cognitive performance
76%
Measured a reduction in biological age markers after 3 months
89%
Reported better sleep quality within the first month
Your 10-Second Daily Longevity Ritual
2 capsules a day. Every day. To feel a decade younger.
01
02
03
Take 2 capsules every morning.
On an empty stomach – 30 minutes before breakfast.
Make it automatic.
Link it to a habit you already do every morning.
Consistency matters more than timing.
The longer you take it, the deeper the cellular renewal goes.
Dive Deeper Into Longevity.Get The Full Tudo Protocol
All the benefits of MIKRON™ Creatine – supercharged with NAD+ for cellular renewal and Magnesium + electrolytes for deep hydration. Take it at the best price and get a free gift.
NAD+ alone
SHINKAI™ NAD+ Longevity Capsules
The only triple-action NAD+ formula – NMN restores, Apigenin protects, TMG preserves.
500mg NMN – NAD+ restoration
500mg TMG – DNA methylation protection
100mg Apigenin – CD38 inhibition
AstraGin® — +67% bioavailability
or
The Tudo Longevity Protocol
Everything in NAD+ – plus Dual-Kinetic creatine and deep electrolyte hydration. Every biological pathway. One daily system.
INCLUDES:SHINKAI™ NAD+ Longevity Capsules
PLUS:MIKRON™ Dual-Kinetic Creatine GummieS
PLUS:Magnesium + Electrolytes FREE GIFT
95% more cellular energy89% stronger muscles87% faster recovery
Japan has more centenarians per capita than any nation on Earth. It's also the country with the strictest supplement manufacturing standards in the world — and that's not a coincidence. A nation that takes longevity seriously doesn't separate "supplement-grade" from "pharma-grade." To them, it's one discipline: the same GMP, the same documentation on every gram, the same precision used to manufacture prescription drugs.
We call this discipline the SHINKAI PRECISION CODE™ — and it's the foundation of every Tudo formula. In SHINKAI™ NAD+ Longevity Capsules, where NMN absorption is the difference between a label claim and a real effect, it shows up as:
SHINKAI™ · 深海 Phospholipid encapsulation inspired by deep-sea biology. NMN bioavailability 3–5x higher than standard forms.
WAKŌ™ · 和光 Multi-stage recrystallization to 99.9%+ purity. Research grade. The standard above the standard.
Formulation philosophy Nothing unnecessary. Everything at therapeutic dose. Every ingredient with a reason.
Athletes, Biohackers, Age Optimizers, Professionals
— 22,000+ Verified Buyers
Ryan M., 31
Professional Cyclist
"By month 2, my power output in the final kilometers measurably improved — the cellular energy difference isn't just felt, it shows up in the data."
SHINKAI™ NAD+ Longevity Capsules
Olivia T., 27
Triathlete
"I train twice a day and recovery used to be my limiting factor — since SHINKAI™ NAD+, I'm adapting faster and my coach noticed before I did."
SHINKAI™ NAD+ Longevity Capsules
Christine W., 44
Marketing Executive
"Six weeks in — better sleep, more energy, zero afternoon crash, and somehow my skin looks different too."
SHINKAI™ NAD+ Longevity Capsules
Sofia R., 38
Pilates Instructor
"The energy stability through hormonal fluctuations is unlike anything I've tried — finally something that works with your biology, not against it."
SHINKAI™ NAD+ Longevity Capsules
George H., 62
Retired Surgeon
"This is the first consumer formula that gets the full picture right — NMN, TMG, Apigenin together — and my inflammatory markers improved in 90 days to prove it."
SHINKAI™ NAD+ Longevity Capsules
Barbara M., 57
Active Grandmother
"I'm 57, my grandkids can't keep up with me on hikes, and my doctor keeps asking what I'm doing differently."
SHINKAI™ NAD+ Longevity Capsules
Lena V., 33
Neuroscientist
"SHINKAI™ phospholipid encapsulation makes the bioavailability difference measurable, not just theoretical — and my NAD+ proxy markers confirm it."
SHINKAI™ NAD+ Longevity Capsules
Felix B., 41
Data Scientist
"Since adding this formula, homocysteine dropped, inflammatory markers improved, and cognitive output increased — the TMG is doing real work."
SHINKAI™ NAD+ Longevity Capsules
Nathan O., 49
Venture Capitalist
"Since starting SHINKAI™ NAD+, the mental fatigue in late afternoon meetings just doesn't hit the same way — and the decisions I make at 6pm are as sharp as the ones I make at 9am."
SHINKAI™ NAD+ Longevity Capsules
Claire T., 43
Surgeon
"Three months in, the mental clarity through long procedures has noticeably improved — I'm more precise when it matters most."
SHINKAI™ NAD+ Longevity Capsules
22,000+Verified Buyers
1,500,000+Servings Taken
4.9/5Average Rating
Backed by leading longevity scientists and physicians
Tudo formulas are developed, reviewed, and endorsed by independent experts in longevity medicine, neuroscience, and cellular biology.
"
By 40, most people have lost nearly half their NAD+ — and they feel it without knowing why. Fatigue, brain fog, slower recovery. This formula addresses the root cause, not the symptoms. NMN through SHINKAI™ delivery is the most direct intervention I've seen in clinical practice.
"
Dr. Elena Vasquez PhDEpigenetics & Biological Age ResearchHarvard Medical School
"
NMN without TMG creates a methylation deficit most people don't know about. This formula is one of the few that addresses it correctly. Combined with SHINKAI™ delivery technology, the bioavailability advantage is real and measurable.
"
Dr. Yuki Tanaka PhDCellular Biology & NAD+ MetabolismOsaka University
"
Poorly absorbed NMN delivers a fraction of the stated dose. SHINKAI™ phospholipid encapsulation increases bioavailability 3–5x over standard forms. You're finally getting what's on the label.
"
Dr. Jonathan Park PhDPharmaceutical Sciences & Nutrient BioavailabilityJohns Hopkins University
"I'm 49 and the afternoon energy crash was getting hard to ignore. Three months in, my afternoons feel a lot more like my mornings used to."
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Mark D.
Verified Buyer
I recommend this product
Wellness concern:Healthy aging, Energy, Longevity
Age Range:35-44
Gender:Male
Usage:6+ month
SHINKAI NAD+
"Six months on this. I feel a lot better than I did at the start of the year — more energy, sleeping better. Hard to point at one thing but this is what changed in my routine."
Was this reviews helpful?
Jenny K.
Verified Buyer
I recommend this product
Wellness concern:Energy, Sleep, Recovery
Age Range:35-44
Gender:Female
Usage:1-3 month
SHINKAI NAD+
"Sleep got deeper around week 3. Not sure if that was the goal but I'll take it."
"The TMG inclusion is what sold me. I've taken NMN before and read about the methylation issue. Glad someone finally formulated it properly."
Was this reviews helpful?
Greg L.
Verified Buyer
I recommend this product
Wellness concern:Energy, Performance
Age Range:55-64
Gender:Male
Usage:3-6 month
SHINKAI NAD+
"Doing what I hoped it would do. Slow change but it's there."
Was this reviews helpful?
Stephanie M.
Verified Buyer
I recommend this product
Wellness concern:Energy, Skin, Healthy aging
Age Range:45-54
Gender:Female
Usage:3-6 month
SHINKAI NAD+
"Three months in. My energy is steadier and my skin looks a little brighter — my friend asked if I changed something. I didn't, just added this."
Was this reviews helpful?
Daniel W.
Verified Buyer
I recommend this product
Wellness concern:NAD+, Mitochondrial, Cellular energy
Age Range:35-44
Gender:Male
Usage:6+ month
SHINKAI NAD+
"Apigenin + TMG + AstraGin in one capsule is rare. Most NMN brands skip the cofactors and call it a day. This actually addresses what NMN needs to work."
Was this reviews helpful?
Lauren B.
Verified Buyer
I recommend this product
Wellness concern:Sleep, Mood, Energy
Age Range:25-34
Gender:Female
Usage:1-3 month
SHINKAI NAD+
"Wasn't expecting much honestly. But my mood is more even and I'm waking up more rested. Don't know how else to describe it."
Was this reviews helpful?
Howard K.
Verified Buyer
I recommend this product
Wellness concern:Healthy aging, Energy, Vitality
Age Range:55-64
Gender:Male
Usage:3-6 month
SHINKAI NAD+
"I'm 62. Feel a bit more like 55 these days."
Was this reviews helpful?
Rachel T.
Verified Buyer
I recommend this product
Wellness concern:Brain fog, Focus, Hormonal
Age Range:45-54
Gender:Female
Usage:1-3 month
SHINKAI NAD+
"Perimenopause hit my brain hard. Started this six weeks ago. The fog is lifting — slowly but it's lifting."
"Recovery between workouts is faster. I lift four days a week and used to feel beat up by Friday. That's not happening now."
Was this reviews helpful?
Sasha O.
Verified Buyer
I recommend this product
Wellness concern:Energy, Healthy aging, Skin
Age Range:35-44
Gender:Female
Usage:3-6 month
SHINKAI NAD+
"Three months in, the change is subtle but real. Not a dramatic before-and-after — more like I just feel more like myself."
Was this reviews helpful?
Brian L.
Verified Buyer
I recommend this product
Wellness concern:Energy, Mental clarity
Age Range:45-54
Gender:Male
Usage:Less than 1 month
SHINKAI NAD+
"Two weeks in and I'm cautiously optimistic. Will update."
Was this reviews helpful?
Nicole H.
Verified Buyer
I recommend this product
Wellness concern:Healthy aging, Skin, Energy
Age Range:55-64
Gender:Female
Usage:6+ month
SHINKAI NAD+
"Been on this 8 months now. My energy is the most consistent it's been since my late 40s. My dermatologist said my skin texture has improved — I credit a few things but this is one of them."
"Tried three other NMN brands before this. None of them included the cofactors that make NMN actually work. The TMG and apigenin are why I'm staying."
Was this reviews helpful?
Trevor M.
Verified Buyer
I recommend this product
Wellness concern:Energy, Workout, Vitality
Age Range:35-44
Gender:Male
Usage:1-3 month
SHINKAI NAD+
"Honestly thinking about picking up a second sport. The energy has nowhere to go."
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Risk-Free
Feel it, or get your money back.
All Batches Are 3rd Party Lab Tested
Every batch is independently tested for identity, potency, and purity. We publish results so you can verify exactly what's in your capsules.
60-Day Risk-Free Trial
NAD+ restoration works gradually — cellular renewal and biological change take time, not days.
Give your body 60 days to respond. If you don't feel a difference, contact us for a full, hassle-free refund.
Simple, Hassle-Free Refunds
We don't believe in forcing belief.
If SHINKAI™ NAD+ Longevity Capsules don't meet your expectations, our support team will process your refund quickly. No forms. No questions asked.
Over 22,000 verified buyers. 4.9/5 average rating. We're confident enough to bet on your experience — because 92% of our customers report a noticeable difference within the first 30 days.
FAQs
The world's first triple-action NAD+ formula — 500mg NMN restores NAD+ levels, 100mg Apigenin blocks CD38 (the enzyme that destroys NAD+), and 500mg TMG protects DNA methylation. Delivered via SHINKAI™ phospholipid technology for 3–5x higher bioavailability than standard forms.
After 30, NAD+ levels decline by up to 1–2% every year. By 50, you may have lost nearly half your NAD+. The result: less cellular energy, slower DNA repair, cognitive decline, and accelerated biological aging. Supplementing with NMN is the most direct way to restore NAD+ levels.
Anyone over 30 who wants to maintain cellular energy, protect their brain, slow biological aging, and extend healthspan. Especially effective for professionals under cognitive load, active adults over 40, women navigating hormonal changes, and anyone focused on longevity.
Take 2 capsules every morning on an empty stomach — 30 minutes before breakfast. Consistency matters more than timing. The longer you take it, the deeper the cellular renewal goes.
TMG (Trimethylglycine) is not optional — it's a metabolic necessity. NMN consumes methyl groups during conversion to NAD+. Without sufficient TMG, NMN supplementation creates a methylation deficit that can actually accelerate biological aging. TMG replenishes methyl groups and protects DNA methylation.
Apigenin is a natural CD38 inhibitor — CD38 is the enzyme that destroys NAD+ faster than your body can replenish it. Most NAD+ supplements ignore CD38 entirely. Without blocking it, much of the NMN you take gets destroyed before it can work. Apigenin is the missing piece in standard NAD+ formulas.
SHINKAI™ is a phospholipid encapsulation technology inspired by deep-sea biology. It wraps NMN molecules in protective lipid layers that survive digestion and deliver active compounds directly into cells — increasing bioavailability 3–5x compared to standard capsules.
Week 1–2: more stable energy, less afternoon fatigue. Week 4+: improved sleep quality, sharper mental clarity. Week 6+: cognitive function measurably improves, recovery accelerates. Week 12+: biological age markers begin to shift. Month 6+: sustained NAD+ restoration creates measurable changes in healthspan.
Yes. SHINKAI™ NAD+ NMN+TMG Longevity Capsules contain no animal-derived ingredients. All compounds are synthetically produced to research-grade purity standards. Suitable for vegans and vegetarians.
Yes — it works synergistically with the full Tudo Protocol. If you take prescription medications, consult your physician before use.
Yes. NMN has been extensively studied and is well-tolerated in clinical trials. WAKŌ™ 99.9%+ research-grade purity ensures you're getting a clean, safe product every time.
60-day money-back guarantee. Full refund. No questions asked.
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TUDO NAD+
Based on 355 verified reviews
Based on 355 verified reviews
